Month: May 2021

Novel AMBRA1-ALK fusion identified by next-generation sequencing in advanced gallbladder cancer responds to crizotinib: a case report

Novel AMBRA1-ALK fusion identified by next-generation sequencing in advanced gallbladder cancer responds to crizotinib: a case report

Gallbladder cancer (GBC) is essentially the most aggressive malignancy of the biliary tract with poor prognosis. Several targetable genetic alterations have been identified in GBC; nevertheless, responses to focused remedy are disappointing. We report a case of a 58-year-old Chinese lady with GBC who was detected with a novel ALK genomic rearrangement and obtained crizotinib after development from first-line …

Novel AMBRA1-ALK fusion identified by next-generation sequencing in advanced gallbladder cancer responds to crizotinib: a case report Read More »