Bringing Gene Therapies for HIV Disease to Resource-Limited Parts of the World

Despite the indisputable fact that 59% of individuals dwelling with HIV (PLHIV) presently obtain viral suppression on antiretroviral remedy (ART), latest beneficial properties in controlling the international HIV/AIDS epidemic could also be threatened: key HIV incidence charges are declining solely modestly, the sustainability of packages to increase ART stays unclear, and the “youth bulge” in sub-Saharan Africa contributes to a rising at-risk inhabitants.1 Although a lot effort has been devoted to prevention interventions, these face main technical and/or implementation challenges.

A complementary method is a secure, efficient, and sturdy intervention that fully eliminates HIV an infection (“eradication”) or that suppresses viremia in the absence of ART (“remission”) (each of these states are referred to as an “HIV treatment” herein). Though a frightening objective, the scientific foundation is evident: long-term remission if not eradication has been noticed in the “Berlin affected person”2 in addition to the “London affected person”three following transplantation of bone marrow progenitor cells missing the viral co-receptor, CCR5; and sturdy remission happens in tens of hundreds of PLHIV (so-called “Elite Controllers”), some of whom (“Exceptional Elite Controllers”) might have eradicated their infections by way of pure immunity.

4,5 Ongoing work over the previous decade means that HIV treatment could be induced by some interventions, alone or together, together with provision of broadly neutralizing antibodies (bNAbs), technology of efficient antiviral CD8+ T cell responses, and knock-out of the viral co-receptor, CCR5.6 Little is thought, nevertheless, about the nature and vulnerabilities of the rebound-competent viral reservoir that persists regardless of ART and about the immunologic management of virus in the absence of ART; at this time’s “greatest bets,” in different phrases, should nonetheless be considered as lengthy photographs.

Initiated by the Bill & Melinda Gates Foundation in 2019, the HIV Frontiers Program goals to transfer work on HIV treatment in the direction of interventions that may in the end be out there to all, most particularly these in resource-limited elements of the world the place the prevalence of illness is excessive (Figure 1). It begins with the premise that the journey might be lengthy (15-25 years) and that it’s going to in the end yield a “single-shot treatment,” i.e., a product that’s delivered percutaneously (“in vivo”) in a single encounter, safely and successfully modifying chosen cells in the physique in order that viral replication and unfold are suppressed and re-infection blocked.

This aspirational objective is probably going to be realized by way of a sequence of progressive interventions that transfer from mixture therapies offered over an extended period of time to these through which cells are modified outdoors of the physique (“ex vivo”) prior to re-infusion.7 The work will construct on present information to advance by way of a sequence of technical and sensible hurdles whereas additionally gathering new information to greatest design a healing intervention for HIV and to decide whether or not and the way it could be used. To get to the level of having a “single-shot treatment” for HIV in hand, two interlocking areas of focus are being pursued: Current Best Bets: To reduce the anticipated time to influence, investments are being made in all of the mandatory parts of a “single-shot” HIV treatment in parallel.

As a vital enabler, the Program is leveraging the appreciable curiosity and sources in biotech/pharma firms that at the moment are growing ex vivo genetic and cell-based interventions; uniquely amongst ongoing efforts, it intends to shift the emphasis of such interventions to supply in vivo, an method that’s more likely to profit these in resource-limited elements of the world. Early types of the “single-shot” treatment would faucet present “greatest bets” (i.e., administration of two or extra bNAbs, induction of a sturdy T cell response in opposition to HIV, and CCR5 knock-out), rapidly pivoting to others ought to they come up, and asking the questions: can these interventions be delivered effectively and safely to acceptable cell populations in vivo;

if that’s the case, can they be related to strategies to detect their failure; and, importantly, is there a viable pathway for product improvement and distribution in sub-Saharan Africa? Incremental steps are being taken to maximize the probability of success, with improvement and validation of novel approaches for focusing on and modifying chosen populations of cells (e.g., hematopoietic stem cells, CD4+ T stem central reminiscence cells, and B cells) in vivo. At the outset, this work is taking benefit of genetic “cures” for sickle cell illness that at the moment are in hand, with early outcomes indicating that substantial scientific profit could be obtained with even incomplete correction of the hemoglobin S genotype (both by modifying the hemoglobin S allele or by upregulating hemoglobin F) in hematopoietic stem cells ex vivo.

8 Successful efforts to modify hematopoietic stem cells in vivo to end in comparable corrections may kind a pathway to the in vivo introduction of modifications aimed toward HIV treatment. If profitable, the final product might be a reasonable composition that’s simply and safely delivered, and designed to impact a sturdy  ought to predictably come up. The HIV Reservoirs Consortium: In this program, a consortium of educational labs has been established to outline the biology of the rebound-competent reservoir of HIV in vivo and, specifically, to uncover circulating non-viral biomarkers that can be utilized to monitor it over time.

Stromal Cell-Derived Factor 1 (CXCL12) Antibody
20-abx135717	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
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Stromal Cell Derived Factor 1 (SDF1) Antibody
20-abx103066	Abbexa	EUR 314.00 EUR 133.00 EUR 815.00 EUR 425.00 EUR 272.00	100 ug 10 ug 1 mg 200 ug 50 ug
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Stromal Cell Derived Factor 1 (SDF1) Antibody
20-abx103067	Abbexa	EUR 411.00 EUR 133.00 EUR 1135.00 EUR 551.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug
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Stromal Cell-Derived Factor 1 (CXCL12) Antibody
abx038296-100ug	Abbexa	100 ug	EUR 391
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Stromal Cell Derived Factor 1 (SDF1) Antibody
20-abx104945	Abbexa	EUR 314.00 EUR 133.00 EUR 815.00 EUR 425.00 EUR 272.00	100 ug 10 ug 1 mg 200 ug 50 ug
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Stromal Cell-Derived Factor 1 (CXCL12) Antibody
20-abx008729	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
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Stromal Cell Derived Factor 1 (SDF1) Antibody
20-abx174652	Abbexa	EUR 843.00 EUR 439.00	1 mg 200 ug
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Stromal Cell Derived Factor 1 (SDF1) Antibody
20-abx174653	Abbexa	EUR 913.00 EUR 467.00	1 mg 200 ug
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Stromal cell-derived factor 1 (CXCL12) Antibody
20-abx326884	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug
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Stromal cell-derived factor 1 (CXCL12) Antibody
20-abx328802	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug
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Stromal Cell Derived Factor 1 (SDF1) Antibody
20-abx178490	Abbexa	EUR 1135.00 EUR 551.00	1 mg 200 ug
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Stromal Cell Derived Factor 1 (SDF1) Antibody
20-abx178491	Abbexa	EUR 1288.00 EUR 620.00	1 mg 200 ug
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Stromal Cell Derived Factor 1 (SDF1) Antibody
20-abx178492	Abbexa	EUR 1497.00 EUR 704.00	1 mg 200 ug
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Stromal cell-derived factor 1 (CXCL12) Antibody
20-abx212182	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
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Stromal cell-derived factor 1 (CXCL12) Antibody
20-abx212969	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
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Stromal Cell-Derived Factor 1 (CXCL12) Antibody
abx232093-100ug	Abbexa	100 ug	EUR 509
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Stromal Cell Derived Factor 1 (SDF1) Antibody (FITC)
20-abx274034	Abbexa	EUR 453.00 EUR 244.00 EUR 1316.00 EUR 634.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug
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Stromal Cell Derived Factor 1 / SDF1 (CXCL12) Antibody
abx411732-01mg	Abbexa	0.1 mg	EUR 704
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Stromal Cell Derived Factor 1 / SDF1 (CXCL12) Antibody
abx411885-01mg	Abbexa	0.1 mg	EUR 704
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Stromal Cell Derived Factor 1 / SDF1 (CXCL12) Antibody
abx412560-01mg	Abbexa	0.1 mg	EUR 704
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Stromal Cell Derived Factor 1 (SDF1) Antibody (Biotin)
20-abx271929	Abbexa	EUR 328.00 EUR 217.00 EUR 885.00 EUR 453.00 EUR 272.00	100 ug 10 ug 1 mg 200 ug 50 ug
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Stromal Cell Derived Factor 1 (SDF1) Antibody (Biotin)
20-abx272660	Abbexa	EUR 425.00 EUR 230.00 EUR 1219.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Active Stromal Cell Derived Factor 1 (SDF1)
4-APA122Hu01	Cloud-Clone	EUR 727.20 EUR 298.00 EUR 2452.00 EUR 884.00 EUR 1668.00 EUR 550.00 EUR 5980.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: P48061 Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 9.1kDa Isoelectric Point: 9.6
Description: Recombinant Human Stromal Cell Derived Factor 1 expressed in: E.coli

Active Stromal Cell Derived Factor 1 (SDF1)
4-APA122Hu02	Cloud-Clone	EUR 772.00 EUR 310.00 EUR 2620.00 EUR 940.00 EUR 1780.00 EUR 580.00 EUR 6400.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: P48061 Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 37.8kDa Isoelectric Point: 8.5
Description: Recombinant Human Stromal Cell Derived Factor 1 expressed in: E.coli

Stromal Cell-Derived Factor 1 alpha Protein
abx060823-10ug	Abbexa	10 ug	EUR 481
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Mouse Stromal cell-derived factor 1 (Cxcl12)
1-CSB-RP092994m	Cusabio	EUR 505.00 EUR 265.00 EUR 1827.00 EUR 766.00 EUR 1218.00 EUR 335.00	100ug 10ug 1MG 200ug 500ug 50ug
MW: 12 kDa Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Mouse Stromal cell-derived factor 1(Cxcl12),partial expressed in E.coli

Recombinant Stromal Cell Derived Factor 1 (SDF1)
4-RPA122Ha01	Cloud-Clone	EUR 503.20 EUR 238.00 EUR 1612.00 EUR 604.00 EUR 1108.00 EUR 400.00 EUR 3880.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: G3I6P7 Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 11.7kDa Isoelectric Point: 10
Description: Recombinant Hamster Stromal Cell Derived Factor 1 expressed in: E.coli

Recombinant Stromal Cell Derived Factor 1 (SDF1)
4-RPA122Hu01	Cloud-Clone	EUR 413.60 EUR 214.00 EUR 1276.00 EUR 492.00 EUR 884.00 EUR 340.00 EUR 3040.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: P48061 Buffer composition: 100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 9.1kDa Isoelectric Point: 9.6
Description: Recombinant Human Stromal Cell Derived Factor 1 expressed in: E.coli

Recombinant Stromal Cell Derived Factor 1 (SDF1)
4-RPA122Hu02	Cloud-Clone	EUR 413.60 EUR 214.00 EUR 1276.00 EUR 492.00 EUR 884.00 EUR 340.00 EUR 3040.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: P48061 Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 40.2kDa Isoelectric Point: 8.5
Description: Recombinant Human Stromal Cell Derived Factor 1 expressed in: E.coli

Recombinant Stromal Cell Derived Factor 1 (SDF1)
4-RPA122Mu01	Cloud-Clone	EUR 458.40 EUR 226.00 EUR 1444.00 EUR 548.00 EUR 996.00 EUR 370.00 EUR 3460.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: P40224 Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 9.2kDa Isoelectric Point: 9.8
Description: Recombinant Mouse Stromal Cell Derived Factor 1 expressed in: E.coli

Recombinant Stromal Cell Derived Factor 1 (SDF1)
4-RPA122Ra01	Cloud-Clone	EUR 494.24 EUR 235.00 EUR 1578.40 EUR 592.80 EUR 1085.60 EUR 394.00 EUR 3796.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: Q9QZD1 Buffer composition: 100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 38.0kDa Isoelectric Point: 8.6
Description: Recombinant Rat Stromal Cell Derived Factor 1 expressed in: E.coli

SDF-1a Stromal Cell-Derived Factor-1 Alpha Mouse Recombinant Protein (CXCL12)
PROTP40224-1	BosterBio	Regular: 10ug	EUR 317
Description: Stromal Cell-Derived Factor-1 alpha Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass of 7921 Dalton. ;The SDF-1a is purified by proprietary chromatographic techniques.

Stromal Cell Derived Factor 4 (SDF4) Antibody
20-abx115870	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul
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Stromal Cell Derived Factor 2 (SDF2) Antibody
abx122010-100ug	Abbexa	100 ug	EUR 391
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Stromal Cell Derived Factor 2 (SDF2) Antibody
20-abx103068	Abbexa	EUR 398.00 EUR 133.00 EUR 1094.00 EUR 537.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug
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Stromal Cell Derived Factor 4 (SDF4) Antibody
20-abx103069	Abbexa	EUR 398.00 EUR 133.00 EUR 1107.00 EUR 537.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug
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Stromal Cell Derived Factor 4 (SDF4) Antibody
20-abx103070	Abbexa	EUR 425.00 EUR 133.00 EUR 1177.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug
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Stromal Cell Derived Factor 4 (SDF4) Antibody
20-abx004039	Abbexa	EUR 411.00 EUR 592.00	100 ul 200 ul
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Stromal Cell Derived Factor 4 (SDF4) Antibody
abx029575-400ul	Abbexa	400 ul	EUR 523
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Stromal Cell Derived Factor 4 (SDF4) Antibody
abx029575-80l	Abbexa	80 µl	EUR 286
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Stromal Cell Derived Factor 4 (SDF4) Antibody
20-abx214889	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
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Stromal Cell Derived Factor 4 (SDF4) Antibody
20-abx214890	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
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Stromal Cell Derived Factor 4 (SDF4) Antibody
abx431576-200ul	Abbexa	200 ul	EUR 384
Shipped within 1-3 working days.

Stromal Cell Derived Factor 4 (SDF4) Antibody
abx237668-100ug	Abbexa	100 ug	EUR 509
Shipped within 5-12 working days.

Stromal Cell Derived Factor 2 (SDF2) Antibody
20-abx301276	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
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Stromal Cell Derived Factor 4 (SDF4) Antibody
20-abx302677	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
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Stromal Cell Derived Factor 4 (SDF4) Antibody
20-abx178493	Abbexa	EUR 1135.00 EUR 551.00	1 mg 200 ug
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SDF-1a Stromal Cell-Derived Factor-1 alpha Human Recombinant Protein, His Tag
PROTP48061-1	BosterBio	Regular: 10ug	EUR 317
Description: Stromal Cell-Derived Factor-1 alpha Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 78 amino acids, having a molecular mass of 9.2 kDa. ;The SDF-1a is fused to 10 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Stromal Cell-Derived Factor 2-Like 1 (SDF2L1) Antibody
20-abx115871	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul
Shipped within 5-10 working days.

Stromal Cell Derived Factor 1 / SDF1 (CXCL12) Antibody (Biotin)
abx411733-50ug	Abbexa	50 ug	EUR 676
Shipped within 1 week.

Stromal Cell Derived Factor 1 / SDF1 (CXCL12) Antibody (Biotin)
abx412561-50ug	Abbexa	50 ug	EUR 676
Shipped within 1 week.

Stromal Cell Derived Factor 1 (SDF1) Monoclonal Antibody (Human)
4-MAA122Hu22	Cloud-Clone	EUR 221.00 EUR 2114.00 EUR 535.00 EUR 274.00 EUR 203.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Pro23~Lys89 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Stromal Cell Derived Factor 1 (SDF1)

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Mouse)
4-PAA122Mu01	Cloud-Clone	EUR 236.00 EUR 2338.00 EUR 586.00 EUR 294.00 EUR 209.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Lys22~Lys89) Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Stromal Cell Derived Factor 1 (SDF1)

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Rat)
4-PAA122Ra01	Cloud-Clone	EUR 243.00 EUR 2457.00 EUR 613.00 EUR 305.00 EUR 212.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Gly21~Lys89) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Stromal Cell Derived Factor 1 (SDF1)

Pig Stromal Cell Derived Factor 1 (SDF1) Protein
20-abx655149	Abbexa	EUR 648.00 EUR 272.00 EUR 1998.00 EUR 773.00 EUR 467.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-15 working days.

Zebrafish Stromal Cell Derived Factor 1 (SDF1) Protein
20-abx655150	Abbexa	EUR 704.00 EUR 286.00 EUR 2165.00 EUR 829.00 EUR 495.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-15 working days.

Human Stromal Cell Derived Factor 1 (SDF1) Protein
20-abx069177	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Mouse Stromal Cell Derived Factor 1 (SDF1) Protein
20-abx069178	Abbexa	EUR 648.00 EUR 272.00 EUR 1943.00 EUR 759.00 EUR 467.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Rat Stromal Cell Derived Factor 1 (SDF1) Protein
20-abx167596	Abbexa	EUR 690.00 EUR 286.00 EUR 2124.00 EUR 815.00 EUR 495.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Human Stromal Cell Derived Factor 1 (SDF1) Protein
20-abx166422	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Stromal Cell-Derived Factor-1 gamma (CXCL12) Protein
20-abx260660	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg
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Stromal Cell-Derived Factor-1 beta (CXCL12) Protein
20-abx261549	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg
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Stromal Cell-Derived Factor-1 alpha (CXCL12) Protein
20-abx261555	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg
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Stromal Cell-Derived Factor-1 alpha (CXCL12) Protein
20-abx261578	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg
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Stromal Cell-Derived Factor-1 beta (CXCL12) Protein
20-abx261579	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg
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Stromal Cell-Derived Factor-1 beta (CXCL12) Protein
20-abx261580	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg
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Stromal Cell-Derived Factor-1 alpha (CXCL12) Protein
20-abx261597	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg
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Stromal Cell-Derived Factor-1 beta (CXCL12) Protein
20-abx262349	Abbexa	EUR 328.00 EUR 6397.00 EUR 230.00	10 ug 1 mg 2 µg
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Stromal Cell Derived Factor 4 (SDF4) Antibody (HRP)
20-abx310592	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
Shipped within 5-10 working days.

Stromal Cell Derived Factor 4 (SDF4) Antibody (FITC)
20-abx310593	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
Shipped within 5-10 working days.

Stromal Cell Derived Factor 4 (SDF4) Antibody (Biotin)
20-abx310594	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
Shipped within 5-10 working days.

Stromal Cell Derived Factor 4 (SDF4) Antibody (Biotin)
abx433478-100ug	Abbexa	100 ug	EUR 453
Shipped within 1-3 working days.

Stromal Cell Derived Factor 2 (SDF2) Antibody (HRP)
20-abx305259	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
Shipped within 5-10 working days.

Stromal Cell Derived Factor 2 (SDF2) Antibody (FITC)
20-abx305260	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
Shipped within 5-10 working days.

Stromal Cell Derived Factor 2 (SDF2) Antibody (Biotin)
20-abx305261	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug
Shipped within 5-10 working days.

Human Stromal cell-derived factor 2 (SDF2)
1-CSB-EP020900HU	Cusabio	EUR 380.00 EUR 214.00 EUR 1309.00 EUR 560.00 EUR 873.00 EUR 262.00	100ug 10ug 1MG 200ug 500ug 50ug
MW: 25.3 kDa Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Stromal cell-derived factor 2(SDF2) expressed in E.coli

Mouse Stromal cell-derived factor 2 (Sdf2)
1-CSB-EP020900MO	Cusabio	EUR 505.00 EUR 265.00 EUR 1827.00 EUR 766.00 EUR 1218.00 EUR 335.00	100ug 10ug 1MG 200ug 500ug 50ug
MW: 26.4 kDa Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Mouse Stromal cell-derived factor 2(Sdf2) expressed in E.coli

Recombinant Stromal Cell Derived Factor 2 (SDF2)
4-RPA477Hu01	Cloud-Clone	EUR 492.45 EUR 235.00 EUR 1571.68 EUR 590.56 EUR 1081.12 EUR 392.00 EUR 3779.20	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: Q99470 Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 25.1kDa Isoelectric Point: 7.3
Description: Recombinant Human Stromal Cell Derived Factor 2 expressed in: E.coli

Recombinant Stromal Cell Derived Factor 4 (SDF4)
4-RPA722Hu01	Cloud-Clone	EUR 530.08 EUR 245.00 EUR 1712.80 EUR 637.60 EUR 1175.20 EUR 418.00 EUR 4132.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: Q9BRK5 Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 25.8kDa Isoelectric Point: Inquire
Description: Recombinant Human Stromal Cell Derived Factor 4 expressed in: E.coli

Recombinant Stromal Cell Derived Factor 4 (SDF4)
4-RPA722Ra01	Cloud-Clone	EUR 544.42 EUR 248.00 EUR 1766.56 EUR 655.52 EUR 1211.04 EUR 427.00 EUR 4266.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: Q91ZS3 Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 24.8kDa Isoelectric Point: 4.7
Description: Recombinant Rat Stromal Cell Derived Factor 4 expressed in: E.coli

Stromal Cell Derived Factor 2 Like Protein 1 (SDF2L1) Antibody
20-abx131567	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Stromal Cell Derived Factor 2 Like Protein 1 (SDF2L1) Antibody
20-abx131568	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Stromal Cell Derived Factor 2 Like Protein 1 (SDF2L1) Antibody
abx027414-400ul	Abbexa	400 ul	EUR 523
Shipped within 5-10 working days.

Stromal Cell Derived Factor 2 Like Protein 1 (SDF2L1) Antibody
abx027414-80l	Abbexa	80 µl	EUR 286
Shipped within 5-10 working days.

Stromal Cell Derived Factor 2 Like Protein 1 (SDF2L1) Antibody
abx237667-100ug	Abbexa	100 ug	EUR 509
Shipped within 5-12 working days.

Stromal Cell Derived Factor 1 (SDF1) Monoclonal Antibody (Human), APC
4-MAA122Hu22-APC	Cloud-Clone	EUR 307.00 EUR 2735.00 EUR 777.00 EUR 386.00 EUR 203.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Pro23~Lys89 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with APC.

Stromal Cell Derived Factor 1 (SDF1) Monoclonal Antibody (Human), Biotinylated
4-MAA122Hu22-Biotin	Cloud-Clone	EUR 283.00 EUR 2064.00 EUR 628.00 EUR 341.00 EUR 207.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Pro23~Lys89 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with Biotin.

Stromal Cell Derived Factor 1 (SDF1) Monoclonal Antibody (Human), Cy3
4-MAA122Hu22-Cy3	Cloud-Clone	EUR 368.00 EUR 3605.00 EUR 995.00 EUR 473.00 EUR 229.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Pro23~Lys89 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with Cy3.

Stromal Cell Derived Factor 1 (SDF1) Monoclonal Antibody (Human), FITC
4-MAA122Hu22-FITC	Cloud-Clone	EUR 266.00 EUR 2208.00 EUR 642.00 EUR 328.00 EUR 182.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Pro23~Lys89 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with FITC.

Stromal Cell Derived Factor 1 (SDF1) Monoclonal Antibody (Human), HRP
4-MAA122Hu22-HRP	Cloud-Clone	EUR 283.00 EUR 2387.00 EUR 690.00 EUR 351.00 EUR 192.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Pro23~Lys89 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with HRP.

Stromal Cell Derived Factor 1 (SDF1) Monoclonal Antibody (Human), PE
4-MAA122Hu22-PE	Cloud-Clone	EUR 266.00 EUR 2208.00 EUR 642.00 EUR 328.00 EUR 182.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Pro23~Lys89 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with PE.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Human, Mouse)
4-PAA122Hu01	Cloud-Clone	EUR 192.00 EUR 1652.00 EUR 430.00 EUR 232.00 EUR 190.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Pro23~Lys89) Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human, Mouse Stromal Cell Derived Factor 1 (SDF1)

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Human, Mouse)
4-PAA122Hu02	Cloud-Clone	EUR 191.00 EUR 1638.00 EUR 427.00 EUR 230.00 EUR 190.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Pro23~Lys89) Buffer composition: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Description: A Rabbit polyclonal antibody against Human, Mouse Stromal Cell Derived Factor 1 (SDF1)

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Mouse), APC
4-PAA122Mu01-APC	Cloud-Clone	EUR 329.00 EUR 3041.00 EUR 854.00 EUR 416.00 EUR 212.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Lys22~Lys89) Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with APC.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Mouse), Biotinylated
4-PAA122Mu01-Biotin	Cloud-Clone	EUR 299.00 EUR 2288.00 EUR 684.00 EUR 363.00 EUR 214.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Lys22~Lys89) Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with Biotin.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Mouse), Cy3
4-PAA122Mu01-Cy3	Cloud-Clone	EUR 397.00 EUR 4013.00 EUR 1097.00 EUR 513.00 EUR 241.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Lys22~Lys89) Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with Cy3.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Mouse), FITC
4-PAA122Mu01-FITC	Cloud-Clone	EUR 283.00 EUR 2452.00 EUR 703.00 EUR 353.00 EUR 189.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Lys22~Lys89) Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with FITC.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Mouse), HRP
4-PAA122Mu01-HRP	Cloud-Clone	EUR 302.00 EUR 2652.00 EUR 756.00 EUR 377.00 EUR 200.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Lys22~Lys89) Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with HRP.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Mouse), PE
4-PAA122Mu01-PE	Cloud-Clone	EUR 283.00 EUR 2452.00 EUR 703.00 EUR 353.00 EUR 189.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Lys22~Lys89) Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with PE.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Rat), APC
4-PAA122Ra01-APC	Cloud-Clone	EUR 340.00 EUR 3203.00 EUR 894.00 EUR 432.00 EUR 217.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Gly21~Lys89) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with APC.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Rat), Biotinylated
4-PAA122Ra01-Biotin	Cloud-Clone	EUR 307.00 EUR 2407.00 EUR 714.00 EUR 375.00 EUR 217.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Gly21~Lys89) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with Biotin.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Rat), Cy3
4-PAA122Ra01-Cy3	Cloud-Clone	EUR 411.00 EUR 4229.00 EUR 1151.00 EUR 535.00 EUR 248.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Gly21~Lys89) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with Cy3.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Rat), FITC
4-PAA122Ra01-FITC	Cloud-Clone	EUR 292.00 EUR 2582.00 EUR 735.00 EUR 366.00 EUR 194.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Gly21~Lys89) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with FITC.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Rat), HRP
4-PAA122Ra01-HRP	Cloud-Clone	EUR 311.00 EUR 2792.00 EUR 791.00 EUR 391.00 EUR 205.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Gly21~Lys89) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with HRP.

Stromal Cell Derived Factor 1 (SDF1) Polyclonal Antibody (Rat), PE
4-PAA122Ra01-PE	Cloud-Clone	EUR 292.00 EUR 2582.00 EUR 735.00 EUR 366.00 EUR 194.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: SDF1 (Gly21~Lys89) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Stromal Cell Derived Factor 1 (SDF1). This antibody is labeled with PE.

Mouse Stromal cell-derived factor 1 (CXCL12) ELISA Kit
abx513062-96tests	Abbexa	96 tests	EUR 668
Shipped within 5-12 working days.

Human Stromal Cell Derived Factor 1 Alpha (SDF1a) Protein
abx670192-10ug	Abbexa	10 ug	EUR 551
Shipped within 1 week.

Mouse Stromal Cell Derived Factor 1 Alpha (SDF1a) Protein
abx670301-10ug	Abbexa	10 ug	EUR 565
Shipped within 1 week.

Human Stromal Cell Derived Factor 1 (SDF1) Protein (Active)
20-abx651443	Abbexa	EUR 996.00 EUR 356.00 EUR 3279.00 EUR 1205.00 EUR 690.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Human Stromal Cell Derived Factor 1 (SDF1) Protein (Active)
20-abx651444	Abbexa	EUR 1052.00 EUR 384.00 EUR 3502.00 EUR 1274.00 EUR 718.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Human CXCL12/ Stromal cell-derived factor 1 ELISA Kit
E0616Hu	Sunlong	1 Kit	EUR 537

Mouse Cxcl12/ Stromal cell-derived factor 1 ELISA Kit
E0357Mo	Sunlong	1 Kit	EUR 546

Mouse Stromal Cell Derived Factor 1 (CXCL12) ELISA Kit
20-abx154644	Abbexa	EUR 6642.00 EUR 3542.00 EUR 825.00	10 × 96 tests 5 × 96 tests 96 tests
Shipped within 5-7 working days.

Mouse Stromal Cell Derived Factor 1 (CXCL12) ELISA Kit
abx050202-96tests	Abbexa	96 tests	EUR 668
Shipped within 5-12 working days.

Rat Stromal Cell Derived Factor 1 (CXCL12) ELISA Kit
abx050203-96tests	Abbexa	96 tests	EUR 668
Shipped within 5-12 working days.

Mouse Stromal Cell Derived Factor 1 (SDF1) CLIA Kit
abx196254-96tests	Abbexa	96 tests	EUR 825
Shipped within 5-12 working days.

Cat Stromal Cell-Derived Factor-1 beta (CXCL12) Protein
20-abx260668	Abbexa	EUR 328.00 EUR 3418.00 EUR 230.00	10 ug 1 mg 2 µg
Shipped within 5-10 working days.

Chicken Stromal Cell Derived Factor 1 (CXCL12) ELISA Kit
abx351129-96tests	Abbexa	96 tests	EUR 825
Shipped within 5-12 working days.

Mouse Stromal Cell Derived Factor 1 (SDF1) CLIA Kit
20-abx491068	Abbexa	EUR 7973.00 EUR 4246.00 EUR 981.00	10 × 96 tests 5 × 96 tests 96 tests
Please enquire.

Pig Stromal Cell Derived Factor 1 (CXCL12) ELISA Kit
abx255562-96tests	Abbexa	96 tests	EUR 825
Shipped within 5-12 working days.

Rat Stromal Cell Derived Factor 1 (CXCL12) ELISA Kit
abx255991-96tests	Abbexa	96 tests	EUR 668
Shipped within 5-12 working days.

Rabbit Stromal Cell Derived Factor 1 (CXCL12) ELISA Kit
abx257075-96tests	Abbexa	96 tests	EUR 786
Shipped within 5-12 working days.

Human Stromal Cell Derived Factor 1 (CXCL12) ELISA Kit
abx253144-96tests	Abbexa	96 tests	EUR 754
Shipped within 5-12 working days.

Mouse Stromal Cell Derived Factor 1 (CXCL12) ELISA Kit
abx254550-96tests	Abbexa	96 tests	EUR 668
Shipped within 5-12 working days.

Recombinant Human Stromal Cell-Derived Factor-1 alpha (CXCL12)
7-02092	CHI Scientific	2µg	Ask for price

Recombinant Human Stromal Cell-Derived Factor-1 alpha (CXCL12)
7-02093	CHI Scientific	10µg	Ask for price

Recombinant Human Stromal Cell-Derived Factor-1 alpha (CXCL12)
7-02094	CHI Scientific	1mg	Ask for price

Recombinant Mouse Stromal Cell-Derived Factor-1 alpha (CXCL12)
7-02098	CHI Scientific	2µg	Ask for price

Recombinant Mouse Stromal Cell-Derived Factor-1 alpha (CXCL12)
7-02099	CHI Scientific	10µg	Ask for price

Recombinant Mouse Stromal Cell-Derived Factor-1 alpha (CXCL12)
7-02100	CHI Scientific	1mg	Ask for price

Recombinant Rat Stromal Cell-Derived Factor-1 alpha (CXCL12)
7-02101	CHI Scientific	2µg	Ask for price

Recombinant Rat Stromal Cell-Derived Factor-1 alpha (CXCL12)
7-02102	CHI Scientific	10µg	Ask for price

Recombinant Rat Stromal Cell-Derived Factor-1 alpha (CXCL12)
7-02103	CHI Scientific	1mg	Ask for price

Recombinant Human Stromal Cell-Derived Factor-1 beta (CXCL12)
7-02104	CHI Scientific	2µg	Ask for price

Recombinant Human Stromal Cell-Derived Factor-1 beta (CXCL12)
7-02105	CHI Scientific	10µg	Ask for price

Recombinant Human Stromal Cell-Derived Factor-1 beta (CXCL12)
7-02106	CHI Scientific	1mg	Ask for price

Recombinant Mouse Stromal Cell-Derived Factor-1 beta (CXCL12)
7-02110	CHI Scientific	2µg	Ask for price

Recombinant Mouse Stromal Cell-Derived Factor-1 beta (CXCL12)
7-02111	CHI Scientific	10µg	Ask for price

Recombinant Mouse Stromal Cell-Derived Factor-1 beta (CXCL12)
7-02112	CHI Scientific	1mg	Ask for price

Recombinant Feline Stromal Cell-Derived Factor-1 beta (CXCL12)
7-02113	CHI Scientific	2µg	Ask for price

Recombinant Feline Stromal Cell-Derived Factor-1 beta (CXCL12)
7-02114	CHI Scientific	10µg	Ask for price

Recombinant Feline Stromal Cell-Derived Factor-1 beta (CXCL12)
7-02115	CHI Scientific	1mg	Ask for price

A strategically centered, multidisciplinary group effort is finishing up research in PLHIV in resource-limited elements of the world in addition to in non-human primate fashions that recapitulate related features of human HIV treatment for all; en route, interventions offering profit for these with sickle cell illness (in addition to different hemoglobinopathies) HIV an infection and through which the reservoir could be systematically perturbed with interventions that would not be utilized in people.